Association between Bone Morphogenic Protein-7 (BMP-7) Polymorphism (rs162316) and Chronic Liver Diseases among Egyptian Patients

Document Type : Original Article

Authors

1 Biochemistry and Molecular Biology Department, Genetic Engineering and Biotechnology Researches Institute (GEBRI), University of Sadat City, Egypt

2 Department of Internal Medicine, Faculty of Medicine, Menoufia University

3 Zoology Department, Faculty of Science, Menoufia University, Egypt

Abstract

The bone morphogenic protein-7 (BMP-7) gene is a member of the transforming growth factor-β (TGF-β) superfamily. BMP-7 is believed to act as a regulator of endogenous control of hepatocytes proliferation and liver homeostasis in adult hepatocytes. The present study aimed to assess the association of single nucleotide polymorphism (SNP), rs162316 (G>A), in BMP-7 gene with the progression of HCV or HBV- chronic liver cirrhosis to hepatocellular carcinoma (HCC). The tetra-primer amplification-refractory mutation system (ARMS-PCR) method was used for rs162316 genotyping. In this study, 150 subjects were divided into 50 healthy controls, 50 HCV or HBV-cirrhotic patients with HCC and 50 HCV or HBV-cirrhotic patients and HCC-free. Results of rs162316 genotyping revealed an association of SNP with 1.14 (0.64-2.03) and 1.43(0.79-2.58) alleles A frequencies (OR, CI 95%) in HCC patients compared to cirrhotic and healthy control groups respectively. For the specific studied SNP of BMP7 gene rs162316, the A allele (AG genotype) and was significantly associated with HCC progression. However, AG genotype of rs162316 may be considered as a predictor for HCC in Egyptian cirrhosis patients.

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