EXPRESSION OF ESTROGEN, PROGESTERONE, AND HUMAN EPIDERMAL GROWTH FACTOR RECEPTORS IN BREAST CANCER IN GMERS MEDICAL COLLEGE AND HOSPITAL GANDHINAGAR, INDIA

Document Type : Original Article

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Pathology Department, GMERS Medical College and Hospital Gandhinagar, India

Abstract

Background: Breast carcinoma is the most common and deadly malignancy of women globally. It is an extremely heterogeneous disease. The aim is to analyze the demographical profile of patients with breast cancer and evaluate the hormonal receptor status and their association with the grading and staging of breast cancer at the time of diagnosis in our hospital. From June 2022 to December 2023, a retrospective study was conducted in the Department of Pathology, at GMERS Medical College Gandhinagar. In this study, we found that the mean age of patients was 56.5+-7.5. Most tumors were Her2Neu negative (73.10%) followed by ER+ (54.8%), and 32.69 % of tumors were PR+. Most of the cases were in stage 2(46.1%) and stage 3(42.30%). Histological grade II was found in 50.94 % of the cases followed by grade III in 42.30% of cases at the time of diagnosis. The most common hormonal receptor expression was ER/PR+, Her2-(54.80%). Regarding, an association of hormonal receptor expression with grading and staging of tumors higher grade (III) and stage (III) were observed in Triple-negative tumors, and lower grade (II) and stage (II) tumor was found in  ER/PR+, Her2- statistically significant tumors (p-value <0.05). A significant association was found between various hormonal expression statuses and stages as well as grade of the breast cancer.

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