Hormonal and Genetic Controls of Hirsutism: Link Between hyperprolactinemia, Polycystic ovary syndrome and Hirsutism

Document Type : Original Article

Authors

1 Department of Biology, College of Science, University of Misan, Maysan, Iraq

2 Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq

Abstract

The definition of hirsutism is when a woman has dark, thick hair that resembles men on her neck, face, chest, and in between thighs. The pathophysiology of hirsutism has been linked to some causes, such as genetic and hormone factors. It has been demonstrated that several such variables contribute to the development of hirsutism. The development of effective hyperprolactinemia for hirsutism diseases has relied on an understanding of the physiological roles and mechanistic functionalities of prolactin and hyperprolactinemia in hirsutism disease. Prolactin was reported to be effective through its action on DHEA and DHEA sulfate levels. The prolactin hormones have been described as affecting the hepatic synthesis of SHBG, simulating the actions of LH, and increasing both ovarian testosterone and adrenal DHEA-S production.
The presented review aims to offer the most recent research on the possible roles of hormones and genes, their impacts on hirsutism, and the function of Reactive oxygen species (ROS) in the pathophysiology of polycystic ovary syndrome (PCOS).
This review examines hormonal and genetic in human hair growth disorder. A focus is made on disorders of well-established genetic and hormonal origin. Such as hirsutism. Reviewed confirms that a complex interaction between hormones, genes, and ROS may underlie the differential of PCOS and hirsutism between patients and the healthy.

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