Histopathological and Hormone receptor changes associated with breast cancer in Missan province

Document Type : Original Article

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Basic Medical Science Department, Nursing College, / Missan University, Iraq.

Abstract

Aim: The present study was performed to evaluate the histopathological examination and Immunohistochemical examination of Estrogen and Progesterone receptors according to the Allred scoring system and the detection of HER2 (c-erbB-2oncoprotien) according to the ASCO immunohistochemical scoring system. Method: The data and tissue specimens were collected from (83) women diagnosed with breast cancer after surgical operation from the laboratory of histopathology in Al-Sadder Teaching Hospital in Missan Province. Results: Histopathological examination of the tissue specimens observed the most breast cancer type was invasive ductal carcinoma (66.2%), followed by intraductal carcinoma (20.4%) and most of the breast cancer states were found in Stage II (40.4), followed Stage III (33.7). The commonest breast cancer was in GradII (54.2), followed by Grad III (28.9), and GradI (16.8). Immunohistochemical expression for ER and PR receptors found strong positive ER receptors (48.1%), moderately positive ER receptors (33.7%) and negative ER receptors (18.2%), also observed strongly positive PR receptors (51.8%), moderately positive PR receptors (31.3%) and negative PR receptors (16.8%). HER2/neu overexpression revealed positive scores in percentage (30.1%) while negative scores were observed in percentage (69.8%) of all cases of breast cancer.
Conclusion: Most breast cancer types were invasive ductal carcinoma followed by intraductal carcinoma. Immunohistochemical expression of ER and PR receptors were strongly positive ER receptors and strongly positive PR receptors. HER2/neu overexpression revealed negative scores, where HER2/neu negative means, the cancer does not tend to grow and spread faster than the HER2/neu positive but is not more likely to respond to the treatment with drugs that target the HER-2 protein.

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