IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA

Mohamed, Saeed Mahmoud Saeed; Amin, Afaf Mosaad; Salih, Aisha Mohmmed Osman; Al-Qadasi, Sabah Ali Mugahed; Sultan, Roa Mohmed Mahmoud

doi:10.21608/jmals.2024.350487

IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA

Document Type : Original Article

Authors

¹ Assistant Professor of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, West Kurdofan University, Sudan.

² Professor of Histochemistry and Cell Biology Department, Medical Research Institute, University of Alexandria, Egypt.

³ Assistant Professor of Biology and Biotechnology Department (Animal Physiology), Faculty of Science and Technology, Al Neelain University, Khartoum-Sudan

⁴ Assistant Professor of Histology, Anatomy and Histology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

⁵ Lecturer of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum- Sudan.

10.21608/jmals.2024.350487

Abstract

In human steroid-sensitive tissue, Estrogen receptors (ERs) have been demonstrated at the mRNA and/or protein levels by using molecular biology and immunohistochemistry techniques. Estrogen receptors are present in endometrial hyperplasia and neoplastic endometrium. The present work aimed to compare the expression of ER as a prognostic biomarker in human endometrial adenocarcinoma versus benign tumors and normal endometrial tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of ER in normal, benign as well as in endometrial adenocarcinoma. Present results showed higher expression of ER in endometrial adenocarcinoma compared to normal and benign endometrial tissues.

Keywords

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