COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER

Al-Qadasi, Sabah Ali Mugahed; Yahia, Mona Abd Alhamed; Mohamed, Saeed Mahmoud Saeed; Sultan, Roa Mohmed Mahmoud

doi:10.21608/jmals.2024.349436

COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER

Document Type : Original Article

Authors

¹ Assistant Professor of Histology, Anatomy and Histology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

² Professor of Histochemistry and Cell Biology Department, Medical Research Institute, University of Alexandria, Egypt.

³ Assistant Professor of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, West Kurdofan University, Sudan.

⁴ Lecturer of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum- Sudan.

10.21608/jmals.2024.349436

Abstract

Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. Cathepsin D (Cath-D) is a soluble lysosomal aspartyl glycoprotease that can degrade the protein components of the matrix and free growth factors therein embedded, thus favoring tumor growth, invasion, and angiogenesis. The present work aimed to compare the expression of GP88 and Cath-D as novel prognostic biomarkers in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of GP88 and Cath-D in normal, benign, and IDC. Present results showed higher expression of GP88, and Cath-D in IDC compared to normal and benign breast tissues.

Keywords

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