Unveiling the Hepatoprotective and Ameliorative Potential of Natural Products in Paracetamol Overdose

Document Type : Original Article

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Zoology Department, Faculty of Science, Damanhur University, Egypt

Abstract

Paracetamol (Acetaminophen; N-acetyl-P- aminophenol) is a broadly used analgesic and antipyretic prescription that can have fatal side effects when used in high dosages. Conventional treatment options for paracetamol overdose are limited and often ineffective, highlighting the need for alternative therapies. In recent years, there has been a growing interest in exploring natural remedies as potential alleviating interventions for paracetamol overdose. This comprehensive review explores the evidence-based natural therapies that have been studied for their effectiveness in reducing paracetamol toxicity. The review examines the mechanisms of action and safety profiles of these natural therapies, as well as their potential limitations and future research directions. The natural remedies discussed in this review include N-acetylcysteine, palm date, milk thistle, curcumin, ginger, and several others. Overall, this review highlights the potential of certain traditional hepatoprotective plants as effective and safe protective options against paracetamol overdose and emphasizes the need for further research to establish their clinical efficacy and safety.

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