Studying the role of Interleukin-6 (IL-6) and C-reactive protein (CRP) in Patients Infected with COVID-19 until Recovery

Document Type : Original Article

Authors

1 Analysis and Laboratories Department, Higher Technological Institute of Applied Health Sciences in Sohag, Ministry of Higher Education, Cairo, Egypt

2 Chest Diseases Department, Medicine –Al-Azhar University

Abstract

Background: Researchers studying medicine are becoming concerned about the pathogen's deciding element as the coronavirus illness 2019 (COVID-19) expands globally. We postulated a relationship between the degree of viral recovery and the amount of interleukin 6 with C-reactive protein.
Aim: Study the level of Interleukin-6 in the case of infection with COVID-19 with C-reactive protein and compare its level in the case of response and non-response to treatment.
Results: The current study included 1,100 people who had symptoms of the common cold and were tested for the presence of SARS-2 RNA using reverse transcriptase-polymerase chain reaction (RT-PCR). 660 cases came back positive, and all cases underwent laboratory tests. Out of 660 patients, 50 patients were selected. Patients with COVID-19 infection and 50 people without COVID-19 infection were randomly assigned to study interleukin and C-RP levels in these patients. Our results showed that there are high statistical significances (P. value < 0.05) in the level of IL-6 and the level of C-RP between patients infected with COVID-19 before and after treatment, and there are also high statistical significances (P. value < 0.05) between patients who responded and those who did not respond to treatment. Conclusion: Il-6 and C-RP levels increase during COVID-19 infection and gradually decrease with treatment until complete recovery. In particular, the levels of Il-6 and C-RP increased significantly in patients who did not respond to treatment, while they decreased in patients who responded to treatment

Keywords

Journal of Medical and Life Science

Articles in Press, Corrected Proof
Available Online from 29 April 2024

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